Soraya Villaseca Herrera

Postdoctoral Research Associate
Cambridge, UK.

About

Postdoctoral Research Associate and academic leader with a PhD in Molecular and Cell Biology, specializing in advanced microscopy and cellular mechanics. Expertly drives pioneering research on cell migration and nuclear dynamics using Zebrafish and Xenopus models, contributing significantly to developmental biology. Proven ability to lead and mentor scientific teams, manage complex projects, and disseminate cutting-edge research through numerous publications and presentations, fostering collaborative academic environments in both the UK and Chile.

Work

Chilean Society for Developmental Biology
|

Director of Postdocs and PhD students

Chile

Summary

Spearheading initiatives to foster collaboration and knowledge exchange among Chilean postdoctoral researchers and PhD students in Developmental Biology, both nationally and internationally.

Highlights

Established and nurtured networks to connect Chilean postdoctoral researchers and PhD students, enhancing collaboration and knowledge transfer through "Ciclos de Seminarios Online"

Organized shared spaces for intellectual exchange, promoting interdisciplinary discussions and strengthening community ties within the Developmental Biology field.

Developed the bimonthly bulletin "Devoletin", designed to inform members, feature interviews with leading developmental biology scientists in Chile and abroad, and promote national and international events in developmental biology.

University of Cambridge
|

Postdoctoral Research Associate

Cambridge, England, UK

Summary

Research on TNC cell migration and nuclear deformation using advanced in vivo and ex vivo models at the University of Cambridge, leveraging cutting-edge microscopy techniques.

Highlights

Investigated TNC cell migration mechanisms and nuclear deformation in highly confined environments using Zebrafish Neural Crest Cells (in vivo) and Xenopus laevis (ex vivo) models.

Utilized spinning disc microscopy, photoablation, and photoconversion systems to precisely manipulate microtubule cytoskeleton.

Executed complex microinjections in both Zebrafish and Xenopus, including transgenic generation and explant/transplant procedures for CNC and TNC cells.

Performed advanced quantitative image analysis using Fiji, MATLAB, and Napari to derive critical insights into cellular processes.

University of Cambridge, Department of Physiology, Development and Neuroscience
|

"Chalk and Talks" Chair

Cambridge, England, UK

Summary

Chaired and managed the weekly "Chalks and Talks" internal seminar series, providing a vital platform for postdoctoral researchers and graduate students to present their research.

Highlights

Facilitated engaging discussions and Q&A sessions, fostering a collaborative and inclusive academic environment within the department.

Managed speaker schedules and introduced presenters, ensuring smooth operation of weekly seminars.

Contributed to the department's diverse and evolving research culture by promoting active participation and knowledge dissemination.

University of Cambridge
|

MPhil Thesis Supervisor

Cambridge, England, UK

Summary

Supervised of an MPhil thesis focusing on microtubule function during nuclear deformation in confined cell migration, guiding comprehensive research.

Highlights

Mentored MPhil student Minjia Pan in advanced biological research, providing guidance on thesis development, experimental design, and scientific analysis.

Oversaw research investigating the role of microtubules in nuclear deformation during confined cell migration in vivo.

Provided expert guidance on data analysis, interpretation, and scientific communication to support successful completion of an MPhil thesis.

University of Cambridge
|

Demonstrator in Genetics (Laboratory sessions)

Cambridge, England, UK

Summary

Will guide students through practical genetics laboratory sessions, ensuring a comprehensive understanding of experimental procedures and scientific principles.

Highlights

Will instruct and supervise students in genetics laboratory techniques, fostering practical skill development and adherence to protocols.

Will provide real-time assistance and clarification during experiments, enhancing student learning and problem-solving abilities.

Will contribute to a dynamic learning environment by facilitating hands-on engagement with genetic concepts.

Universidad de Concepcion
|

MSc Thesis Supervisor

Concepcion, Biobío, Chile

Summary

Supervised an MSc thesis on the functional study of Ric-8A/Gaq in dorsal mesoderm formation in Xenopus tropicalis, guiding comprehensive research.

Highlights

Mentored MSc student Maria Jose Ruiz through the entire thesis process, from experimental design to data interpretation.

Universidad Santo Tomas
|

Lecturer in Biochemistry and Cell Biology

Concepcion, Biobío, Chile

Summary

Delivered comprehensive lectures and laboratory sessions in Biochemistry and Cell Biology to university students, enhancing their foundational scientific understanding.

Highlights

Designed and taught engaging curriculum for Biochemistry and Cell Biology, impacting student comprehension and academic performance.

Conducted hands-on laboratory sessions, providing practical experience in key biochemical and cellular techniques.

Assessed student progress and provided constructive feedback, contributing to their scientific development.

Universidad de Concepción
|

Teaching Assistant in Biochemistry and Molecular Biology

Concepcion, Biobío, Chile

Summary

Supported faculty in delivering core Biochemistry and Molecular Biology courses, facilitating student learning through practical assistance and instructional support.

Highlights

Assisted in laboratory sessions, guiding students through complex experiments and ensuring adherence to safety protocols.

Provided group tutoring, clarifying challenging concepts and improving student understanding.

Contributed to the preparation of course materials (seminars) and grading, enhancing the overall educational experience for students.

Universidad de Concepcion
|

Undergraduate Thesis Supervisor

Concepcion, Biobío, Chile

Summary

Supervised an undergraduate thesis investigating the function of Ric-8A/Gaq during cranial neural crest cell migration in Xenopus tropicalis.

Highlights

Guided undergraduate student Gabriel Romero in conducting research on Ric-8A/Gaq's role in cranial neural crest cell migration.

Provided mentorship on experimental methodology, data analysis, and scientific literature review for thesis completion.

“Las Higueras" Hospital, Servicio de Salud Talcahuano
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Teaching Assistant in “Internado sector Salud" for Biochemistry

Talcahuano, Biobío, Chile

Summary

Provided instructional support for biochemistry within the "Internado sector Salud" program, guiding students in clinical applications.

Highlights

Assisted in teaching biochemistry principles relevant to health sector internships, bridging academic knowledge with practical clinical scenarios.

Mentored students in understanding biochemical processes critical for health diagnosis and treatment.

Facilitated learning experiences that prepared students for real-world applications in medical and health-related fields.

“Las Higueras" Hospital, Servicio de Salud Talcahuano
|

Temporary Biochemist, Molecular Biology Division

Talcahuano, Biobío, Chile

Summary

Performed critical qPCR analysis and validation for viral panel diagnostics, contributing to infectious disease detection and public health.

Highlights

Executed qPCR analysis for a viral panel, ensuring accurate and timely diagnosis of infectious diseases including respiratory viruses, HPV, and HIV.

Validated diagnostic protocols, enhancing the reliability and efficiency of molecular testing within the hospital's Molecular Biology Division.

Contributed to public health surveillance by providing precise laboratory results for critical viral pathogens.

Universidad Católica del Norte
|

Teaching Assistant in Biomedical Sciences

La Serena, Coquimbo, Chile

Summary

Supported online instruction in Biomedical Sciences, contributing to student engagement and comprehension in a remote learning environment.

Highlights

Delivered online assistance for Biomedical Sciences courses, adapting teaching methods for effective remote delivery.

Provided virtual support and resources to students, enhancing their learning experience and academic success.

Contributed to the development of engaging online content and interactive learning activities.

Education

Universidad de Concepcion
Concepcion, Biobío, Chile

PhD

Molecular and Cell Biology

Courses

Studying how the heterotrimeric G protein Gai2 controls cell polarity and microtubules dynamics during Cranial Neural Crest cell migration in Xenopus, using confocal and super resolution microscopy.

University College London
London, England, UK

PhD Internship

Cell and Developmental Biology

Courses

Studying microtubules and focal adhesion dynamics in ex vivo conditions using confocal and TIRF microscopy.

Universidad de Concepcion
Concepcion, Biobío, Chile

MSc

Biochemistry and Bioinformatics

Courses

Thesis: Studying how the heterotrimeric G protein Gai2 and its relationship with Ric-8A as a non-canonical GEF during Cranial Neural Crest cell migration in Xenopus (MSc-undergrade articulation).

Phyton

R

Mollecular Docking

Proteins modelling

Universidad de Concepcion
Concepcion, Biobío, Chile

Bachelor of Science

Biochemistry

Courses

Studying how the heterotrimeric G protein Gai2 and its relationship with Ric-8A as a non-canonical GEF during Cranial Neural Crest cell migration in Xenopus (MSc-undergrade articulation).

Awards

SELFO Travel Award to assist EMBO course Optics, Forces and Development in Santiago, Chile

Awarded By

EMBO

Awarded travel assistance for participation in a specialized EMBO practical course focusing on Optics, Forces and Development.

BSDB Travel Award to assist 5th Hands-on Zebrafish Xenografts Course in Lisbon, Portugal

Awarded By

BSDB

Received travel award to attend the 5th Hands-on Zebrafish Xenografts Course, enhancing practical skills in advanced research techniques.

Postgraduate Fellowship for PhD thesis writing

Awarded a fellowship to support dedicated time for the completion of PhD thesis writing.

ANID Fellowship for PhD internship at University College London

Awarded By

ANID

Granted a fellowship to fund a PhD internship at University College London, facilitating international research experience.

Best Cover Photo for Development Journal

Awarded By

Development Journal, The Company of Biologists

Recognized for an outstanding cover photo featured in Development Journal, highlighting visual scientific communication excellence.

Best Poster Presentation at the IX Latin American Society for Developmental Biology

Awarded By

Latin American Society for Developmental Biology

Received an award for the best poster presentation, recognizing excellence in scientific communication and research dissemination.

ANID fellowship for PhD studies

Awarded By

ANID

Awarded a fellowship to support doctoral studies, enabling advanced research in molecular and cell biology.

Biological Science Faculty Fellowship for MSc-undergrad Articulation program

Awarded By

Biological Science Faculty

Granted a fellowship for participation in the MSc-undergraduate articulation program, supporting integrated academic progression.

"Academic Excellence” Fellowship for undergraduate studies

Received a fellowship recognizing academic excellence during undergraduate studies, supporting scholarly pursuits.

Publications

In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments

Published by

bioRxiv

Summary

(under revision in Nature Cell Biology) bioRxiv 2025.06.05.658077

Gai2 Interaction with EB1 Controls Microtubule Dynamics and Rac1 Activity in Xenopus Neural Crest Cell Migration.

Published by

Development

Summary

152 (8): dev204235.

Collective migration in complex environments: The case of the trunk neural crest.

Published by

Current Topics in Developmental Biology

Summary

ISSN 0070-2153. (Book Chapter)

Gai protein subunit: A step toward understanding its non-canonical mechanisms.

Published by

Front Cell Dev Biol.

Summary

10:941870.

Development, July 2018; 145 (13). The Company of Biologists

Published by

The Company of Biologists

Summary

Journal Cover

Ric-8A, a GEF for heterotrimeric G-proteins, controls cranial neural crest cell polarity during migration. Mechanisms of Development.

Published by

Mechanisms of Development

Summary

154:170-178.

The Ric-8A/Galpha13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration.

Published by

Development

Summary

145 (22). Pii: dev164269.

Xenopus as a model organism to study heterotrimeric G protein pathway.

Published by

Genesis

Summary

55.

Expression profiles of the G subunits during Xenopus tropicalis embryonic development

Published by

Gene Expression Pattern

Summary

22: 15-25

Languages

English

Fluent

Spanish

Native

Certificates

EMBO practical course: Optics, Forces and Development

Issued By

EMBO

5th Hands-on Zebrafish Xenografts Course

Issued By

Champalimaud Foundation

CBIAS Napari Workshop 2024

Issued By

Francis Crick Institute

Introduction to Image Analysis 2024, RMS

Issued By

RMS

Animal Licence (PIL A/B) to work with zebrafish

Issued By

UK Home Office

International course: Biological processes during Development

Issued By

Universidad de Concepcion

EMBO practical course for Developmental Biology: QUINTAY- CIMARQ

Issued By

EMBO

Skills

Microscopy & Imaging

Spinning Disc Timelapse Microscopy, Confocal Microscopy, Super Resolution Microscopy, 2-Photon Laser Ablation, TIRF Microscopy, Live Cell Imaging, Quantitative Image Analysis.

Data Analysis Software

Fiji, MATLAB, Napari.

Leadership & Mentorship

Project Supervision, Teaching, Seminar Series Chair, Academic Mentorship, Community Building, Stakeholder Engagement.

Scientific Communication

Publications, Poster Presentations, Oral Presentations, Seminar Facilitation, Scientific Writing.

Cell/Molecular Biology Techniques

Microinjections (Zebrafish, Xenopus), Transgenic Generation (Zebrafish), Explants and Transplants (CNC, TNC cells in Xenopus), qPCR, Viral Panel Validation, Cloning, Proteins interaction: Co-IP, PLA, FRET, RNAseq, Xenografts.

Cell & Developmental Biology

Neural Crest Cell Migration, Cell Polarity, Microtubule Dynamics, Focal Adhesion Dynamics, Nuclear Deformation, Zebrafish Model, Xenopus Laevis Model, Zebrafish xenografts, Cell culture.